Knowledge and sourcing
Peptides beyond GLP-1
Where the evidence thins out, and saying so.
Members ask about other peptides constantly, and pretending otherwise would send them somewhere worse. So this circle exists, and its defining feature is honesty about how thin the human evidence is for most of what gets discussed.
For a handful of compounds there is real trial data. For most, there is animal work, a mechanism story and a great deal of marketing. We say which is which every single time, and we say plainly that material sold for research use only is not approved for human use.
Who this circle is for
- You have questions about compounds outside the GLP-1 and GIP class
- You want the evidence position stated plainly
- You have read the literature and can help others read it
Agreements here
- Research-use-only material is not approved for human use, and we say so every time
- No sourcing, brokering or price talk in this circle — that belongs in the sourcing circle, with its own rules
- We name the evidence level for every compound discussed: trial, early trial, animal only, or mechanism story
Survodutide and the triple agonist pipeline
Bunny11 replies
Survodutide and the triple agonist pipeline Writing it down partly to work out what I actually think. Evidence question. I would rather have an honest "we do not know" than a confident…
Semaglutide and cagrilintide in combination — what is published
Flossie13 replies
Semaglutide and cagrilintide in combination — what is published — putting it in its own thread so it does not get lost in the check-in. I have read the paper and I am not sure I have…
What a phase 1 result can and cannot tell you
Fabian14 replies
What a phase 1 result can and cannot tell you Writing it down partly to work out what I actually think. Evidence question. I would rather have an honest "we do not know" than a confident…
Growth hormone secretagogues, honestly assessed
Wells17 replies
Growth hormone secretagogues, honestly assessed — putting it in its own thread so it does not get lost in the check-in. I have read the paper and I am not sure I have understood it. What I…
AOD-9604 and a trial that did not find what people say it found
Bunny20 replies
AOD-9604 and a trial that did not find what people say it found Writing it down partly to work out what I actually think. Putting this here because I do not want to be sold anything, I…
How I decided not to take something after reading about it
Wells24 replies
Something I have been sitting with: How I decided not to take something after reading about it Not looking for advice so much as other people's experience. Putting this here because I do…
What is the actual human evidence for BPC-157
Idris24 replies
What is the actual human evidence for BPC-157 — putting it in its own thread so it does not get lost in the check-in. Evidence question. I would rather have an honest "we do not know" than…
CJC-1295 and the difference between a mechanism and an outcome
Wells20 replies
Starting a thread on this because it keeps coming up in ones and twos: CJC-1295 and the difference between a mechanism and an outcome Evidence question. I would rather have an honest "we…
Retatrutide: what phase 2 showed and what it did not
Tacita24 replies
Retatrutide: what phase 2 showed and what it did not Writing it down partly to work out what I actually think. Putting this here because I do not want to be sold anything, I want to know…
The gap between a patent and a proven treatment
Bunny23 replies
The gap between a patent and a proven treatment — putting it in its own thread so it does not get lost in the check-in. I have read the paper and I am not sure I have understood it. What I…
Why animal data is not a small version of human data
Abram23 replies
A question rather than an update: Why animal data is not a small version of human data Evidence question. I would rather have an honest "we do not know" than a confident answer. I have…
Tesamorelin is a licensed medicine and gets confused with things that are not
Flossie24 replies
A question rather than an update: Tesamorelin is a licensed medicine and gets confused with things that are not Evidence question. I would rather have an honest "we do not know" than a…
Why so much of this is marketed rather than studied
Tamar22 replies
Why so much of this is marketed rather than studied — putting it in its own thread so it does not get lost in the check-in. Putting this here because I do not want to be sold anything, I…
Orforglipron and the oral pipeline
Tacita23 replies
A question rather than an update: Orforglipron and the oral pipeline Evidence question. I would rather have an honest "we do not know" than a confident answer. The thing that has surprised…